Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

mtm-1  

Sequence Name

Y110A7A.5  

WB ID

WBGene00003475  

Description

mtm-1 encodes a myotubularin orthologous to human MTM1 (OMIM:300415, mutated in myotubular myopathy), MTMR1 (OMIM:300171), and MTMR2 (OMIM:603557, mutated in type 4B1 Charcot-Marie-Tooth disease); mtm-1(RNAi)suppresses the endocytosis defect of let-512 mutants, indicating that MTM-1 negatively regulates LET-512 (a phosphatidylinositol 3-kinase orthologous to yeast Vps34).