Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

dop-1  

Sequence Name

F15A8.5  

WB ID

WBGene00001052  

Description

dop-1 encodes a D1-like dopamine receptor; dop-1 is required cell autonomously in the touch neurons for modulation of mechanosensory behaviors such as tap habituation; in addition, dop-1 is required for regulation of locomotion via antagonism of the DOP-3 D2-like dopamine receptor in cholinergic neurons; when expressed in tissue culture cells, DOP-1 activity is stimulated by dopamine and to a lesser extent, by norepinephrine and epinephrine; when coexpressed with bovine or C. elegans GalphaS, DOP-1 stimulates potassium channel activity; DOP-1 is expressed in several different types of cells including mechanosensory neurons, cholinergic motor neurons, interneurons, excretory gland cells, head muscles, and neuronal support cells; DOP-1 localizes to the plasma membrane; dop-1 expression in the RIS interneuron is regulated by the LIM-6 homeodomain protein.