Module
- Number
- 169
- Regulatory Genes
- 6
- Module Genes
- 8
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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oma-2 | ZC513.6 | WBGene00003865 | 800 |
The oma-2 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-1; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation.
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gla-3 | T02E1.3 | WBGene00011376 | 249 |
gla-3 encodes a TIS11-like protein with two CCCH-like zinc-finger domains that inhibits apoptosis in the germline, and weakly inhibits RAS signalling in vulval development along with RAS-induced muscle protein degradation; GLA-3 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; gla-3 is expressed in the germline of L4 larvae and adults, and interacts with mpk-1 both genetically and physically; gla-3 requires core apoptotic proteins (CED-3 and CED-4) for its excess apoptotic mutant phenotype, but not others (CEP-1, CLK-2, or HUS-1) required for DNA damage-induced apoptosis; gla-3 mutants have increased germline apoptosis and reduced brood size due to defective pachytene exit from meiosis I, and also show weak enhancment of the multivulva phenotype of let-60(gf) or lip-1(zh15) mutations; gla-3 mutants have temperature-sensitive progressive muscle dystrophy, consistent with hyperactivation of the RAS/MAPK pathway in muscle cells; gla-3(RNAi) hermaphrodites display elevated levels of physiological germline apoptosis, independent of CEP-1.
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cey-3 | M01E11.5 | WBGene00000474 | 226 |
cey-3 encodes a protein with a cold-shock/Y-box domain; CEY-3 associates with CGH-1, CEY-2, and CEY-4 in cytoplasmic particles of the gonad and early embryo.
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cey-2 | F46F11.2 | WBGene00000473 | 150 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
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H02I12.5 | H02I12.5 | WBGene00010353 | 139 | View | |
tbx-7 | ZK328.8 | WBGene00006544 | 125 |
tbx-7 encodes one of 21 C. elegans T-box transcription factors; in large-scale RNAi screens for early embryonic defects, loss of tbx-7 activity results in no obvious abnormalities; thus, the precise role of tbx-7 in C. elegans development and/or behavior is not yet known.
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CLR Predictions
86 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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cbd-1 | H02I12.1 | WBGene00010351 |
cbd-1 encodes a large (1319-residue) protein with 12 chitin-binding peritrophin-A domains; cbd-1(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, perhaps because of defects in chitin and eggshell synthesis; like CEJ-1 and CPG-2, CBD-1 may participate in eggshell synthesis and early embryonic development; CBD-1's multiple peritrophin-A domains might enable mechanical cross-linking of chitin.
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cey-2 | F46F11.2 | WBGene00000473 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
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cpg-1 | C07G2.1 | WBGene00000465 |
cpg-1 encodes, by alternative splicing, two isoforms of a protein with three chitin-binding peritrophin-A domains and two mucin-like regions; CPG-1 is individually dispensable for normal embryonic development; however, CPG-1 and CPG-2 are jointly required for osmotic integrity of early embryos, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; CPG-1, like CPG-2, is covalently linked to chondroitin, which itself is required for vulval morphogenesis, polar-body extrusion, and separation of the eggshell from the embryonic plasma membrane; cpg-1 mRNA, like that of cpg-2, is expressed specifically in the adult hermaphrodite germ line and is bound by GLD-1; CPG-1 has five potential chondroitin attachment sites, one of them verified by mass spectrometry, and transgenic CPG-1 synthesized in mammalian cells carries chondroitin sulfate chains; CPG-1's multiple peritrophin-A domains may enable mechanical cross-linking of chitin.
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cpg-3 | R06C7.4 | WBGene00011063 |
cgp-3 encodes a putatively secreted protein with an N-terminal low-complexity domain containing 15 potential chondroitin attachment sites, and a C-terminal EGF-like region; cpg-3 mRNA is enriched in oogenesis, but CPG-3 has no obvious function in mass RNAi assays.
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egg-2 | R01H2.3 | WBGene00019811 | View | |
F22B3.4 | F22B3.4 | WBGene00009035 |
F22B3.4 encodes a putative glucosamine-fructose 6-phosphate aminotransferase, paralogous to F07A11.2, thought to catalyse the first step of the hexosamine pathway to UDP-N-acetylglucosamine or UDP-N-acetylgalactosamine; F22B3.4 transcripts are enriched during oogenesis; F22B3.4(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis.
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plk-3 | F55G1.8 | WBGene00004044 | View | |
rme-2 | T11F8.3 | WBGene00004374 |
rme-2 encodes a member of the low-density lipoprotein (LDL) receptor superfamily; RME-2 functions as the C. elegans yolk receptor whose activity is required for yolk uptake during oogenesis; RME-2 is expressed in developing oocytes where it localizes at or near the cell surface.
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