Module
- Number
- 15
- Regulatory Genes
- 5
- Module Genes
- 49
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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Y38E10A.6 | Y38E10A.6 | WBGene00012584 | 313 | View | |
Y52B11A.9 | Y52B11A.9 | WBGene00013128 | 234 | View | |
gei-11 | F32H2.1 | WBGene00001568 | 229 |
gei-11 encodes a protein that contains Myb DNA-binding domains and is homologous to mammalian SNAPC4, required for RNA polymerase II and III transcription of snRNA genes; GEI-11 is required for ventral enclosure during embryonic development, as well as for normal rates of postembryonic growth; GEI-11 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis.
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hmg-4 | T20B12.8 | WBGene00001974 | 206 |
hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
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W04D2.4 | W04D2.4 | WBGene00012243 | 175 | View |
CLR Predictions
62 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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apc-2 | K06H7.6 | WBGene00000143 |
apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
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athp-1 | C44B9.4 | WBGene00008081 | View | |
brc-2 | T07E3.5 | WBGene00020316 |
brc-2 encodes a BRC domain-containing protein that is homologous to human BRCA2 which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185); in C. elegans, BRC-2 activity is essential for RAD-51-mediated repair of meiotic and radiation-induced double-strand breaks (DSBs); BRC-2 physically interacts with RAD-51 and single-stranded DNA and is required for proper localization of RAD-51 to sites of DNA damage and stabilization of RAD-51-DNA filaments; BRC-2 can also promote RAD-51-independent DSB repair via single-strand annealing (SSA) when the homologous recombination (HR) and nonhomologous end joining pathways (NHEJ) are compromised; in nonirradiated animals, BRC-2 is seen at diffuse, low levels in germline nuclei, but upon radiation treatment BRC-2 localizes to discrete foci that coincide with presumptive sites of DNA damage.
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C08H9.3 | C08H9.3 | WBGene00007464 | View | |
C27A12.9 | C27A12.9 | WBGene00016159 | View | |
C27C12.1 | C27C12.1 | WBGene00007771 | View | |
C48B6.3 | C48B6.3 | WBGene00016741 | View | |
cep-1 | F52B5.5 | WBGene00000467 |
cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells.
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csn-1 | Y59A8A.1 | WBGene00000813 |
csn-1 encodes an ortholog of subunit 1 of the COP9 signalosome complex (CSN1), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; in mass RNAi assays, csn-1 is required for embryonic viability, maintenance of the germline, and general health.
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F29A7.6 | F29A7.6 | WBGene00017916 | View | |
F56A6.4 | F56A6.4 | WBGene00018923 | View | |
F56H1.5 | F56H1.5 | WBGene00018995 |
F56H1.5 encodes a putative ATP/ADP-activated metallocarboxypeptidase that may function in vivo as an alpha-tubulin C-terminal tyrosine carboxypeptidase; F56H1.5 is orthologous to murine AGTPBP-1/Nna1/pcd (upregulated in damaged mouse spinal cord and mutated in Purkinje cell degeneration) and human AGTPBP1 (OMIM:606830); murine AGTPBP-1 is genetically required for tubulin carboxypeptidase activity in vivo, and F56H1.5's nearest paralog EEED8.6 has biochemical traits consistent with tubulin carboxypeptidase activity; F56H1.5 and its mammalian AGTPBP1 orthologs, along with other proteins, comprise a M14D3 peptidase subfamily.
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F59H5.1 | F59H5.1 | WBGene00019130 |
F59H5.1 encodes an unfamiliar protein with a low-complexity N-terminal region and a C-terminal DUF545 motif (of unknown function, found solely in nematode proteins); F59H5.1 is expressed in neuronal head ganglia, intestinal cells, hypodermal cells, and coelomocytes, with strong expression in embryos; F59H5.1 has no obvious function or phenotype in RNAi assays, whether in a normal background or in goa-1(-) or goa-1(gf) mutant backgrounds.
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fbxa-107 | Y37H2A.4 | WBGene00012564 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
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K07C5.3 | K07C5.3 | WBGene00010626 | View | |
K12H6.2 | K12H6.2 | WBGene00019683 | View | |
lsd-1 | T08D10.2 | WBGene00011615 |
T08D10.2 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; T08D10.2 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor.
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mrt-2 | Y41C4A.14 | WBGene00003417 |
mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality.
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mut-7 | ZK1098.8 | WBGene00003504 |
mut-7 encodes a homolog of RnaseD that represses transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages; also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers; cellular fractionation experiments indicate that MUT-7 is expressed in adult worms, and resides in a complex in both the cytosol and nucleus; in the cytosolic complex, MUT-7 interacts with RDE-2, a novel protein also required for RNA interference.
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pig-1 | W03G1.6 | WBGene00021012 |
pig-1 encodes an ortholog of the human MELK serine/threonine kinase (OMIM:607025); PIG-1 is cytoplasmic, and is required for normal polarity in asymmetrical cell divisions yielding apoptotic cells versus neurons; whereas normal HSN/PHB and Q.p neuroblast divisions yield daughter cells that differ in size, those of pig-1 mutants are abnormally equal in size, and produce excess neurons; pig-1 acts cell-autonomously in the Q.p lineage; pig-1 is ubiquitously expressed in early embryos, broadly expressed in dividing larval cells, and silent in adults; the pig-1 phenotype is enhanced by ced-3 mutants, perhaps because mutations in pig-1 transform cell fates but fail to fully suppress apoptosis; pig-1 phenotypes are maternally rescued, probably due to pig-1 transcripts in the hermaphrodite germ line.
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R02D3.4 | R02D3.4 | WBGene00019822 | View | |
R05H10.3 | R05H10.3 | WBGene00011044 | View | |
rsr-1 | F28D9.1 | WBGene00004706 | View | |
secs-1 | D1054.13 | WBGene00008379 | View | |
T09F3.5 | T09F3.5 | WBGene00011664 |
T09F3.5 encodes a novel protein.
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T12E12.2 | T12E12.2 | WBGene00020463 | View | |
taf-12 | Y56A3A.4 | WBGene00006396 |
taf-12 encodes a homolog of transcription initiation factor TFIID 20/15 kDa subunits (TAFII-20/TAFII-15) with a glutamine/asparagine-rich N-terminal domain and a a TFIID-like C-terminal domain.
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tag-124 | E02H1.3 | WBGene00006473 |
E02H1.3 encodes a putative tRNA pseudouridine synthase orthologous to human PUS3 and S. cerevisiae DEG1; E02H1.3 is coexpressed with pme-2 in an operon, and thus, like PME-2, may function in DNA repair.
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tag-235 | M03C11.4 | WBGene00044069 | View | |
tbck-1 | C33F10.2 | WBGene00016352 | View | |
W04B5.5 | W04B5.5 | WBGene00021022 |
The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase.
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xpg-1 | F57B10.6 | WBGene00019004 |
F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease.
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Y105E8B.6 | Y105E8B.6 | WBGene00013691 | View | |
Y23H5A.2 | Y23H5A.2 | WBGene00021269 |
Y23H5A.2 encodes a Caenorhabditis-specific protein, without obvious similarities or motifs; Y23H5A.2 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51.
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Y32H12A.2 | Y32H12A.2 | WBGene00021311 | View | |
Y34D9A.3 | Y34D9A.3 | WBGene00021329 | View | |
Y37D8A.21 | Y37D8A.21 | WBGene00012558 | View | |
Y37E11B.6 | Y37E11B.6 | WBGene00021378 |
Y37E11B.6 encodes an ortholog of Rpp21 (Rpr2), a protein subunit of the endoribonuclease RNAse P, which cleaves tRNA precursors to produce their mature 5' end.
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Y37E3.1 | Y37E3.1 | WBGene00021346 | View | |
Y38C9A.1 | Y38C9A.1 | WBGene00021411 | View | |
Y38E10A.6 | Y38E10A.6 | WBGene00012584 | View | |
Y48E1C.2 | Y48E1C.2 | WBGene00013015 | View | |
Y66D12A.7 | Y66D12A.7 | WBGene00013433 | View | |
Y67D2.7 | Y67D2.7 | WBGene00022057 | View | |
Y67H2A.2 | Y67H2A.2 | WBGene00013461 | View | |
ZK1058.5 | ZK1058.5 | WBGene00014205 | View | |
ZK546.5 | ZK546.5 | WBGene00022762 | View | |
ZK616.2 | ZK616.2 | WBGene00022772 | View | |
ZK673.3 | ZK673.3 | WBGene00014059 |
ZK673.3 encodes a protein with a THAP or THAP-like domain required for embryonic development; other proteins with THAP or THAP-like domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
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