Transcription regulatory networks in Caenorhabditis elegans
Gene
- Public Gene Name
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mrt-2
- Sequence Name
- Y41C4A.14
- WB ID
- WBGene00003417
- Description
-
mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality.
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