Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

nhr-69  

Sequence Name

T23H4.2  

WB ID

WBGene00003659  

Description

nhr-69 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-69 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-69 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-69 in C. elegans development and/or behavior is not yet known; nhr-69 is expressed strongly in the gut and hypodermis at all stages and is detected in the uterus during the late L4 and adult stages; nhr-69 expression is also occasionally detected in the rectal epithelia and posterior pharynx.