Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

sdhb-1  

Sequence Name

F42A8.2  

WB ID

WBGene00006433  

Description

sdhb-1 encodes the C. elegans ortholog of human succinate dehydrogenase subunit B (SDHB; OMIM:185470, mutations lead to extraadrenal pheochromocytoma) which contains several iron-sulfur (Fe-S) clusters and functions to transfer electrons from the A (SDHA) subunit to the membrane-associated C (SDHC) subunit; RNAi screens indicate that sdhb-1 activity is essential for embryonic and larval development, as well as for normal brood sizes, body morphology, osmoregulation, and growth rate; sdhb-1 is widely expressed in larvae and adults and is predicted to localize to mitochondria.