Module
- Number
- 12
- Regulatory Genes
- 2
- Module Genes
- 50
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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rab-3 | C18A3.6 | WBGene00004267 | 935 |
rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.
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sem-4 | F15C11.1 | WBGene00004773 | 156 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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CLR Predictions
46 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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abts-3 | F57F10.1 | WBGene00019018 |
abts-3 encodes an anion transporter; abts-3 promoter gfp fusions are expressed in neurons and hypodermal cells in a pattern coincident with abts-1.
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C14B9.3 | C14B9.3 | WBGene00015753 | View | |
C15C8.1 | C15C8.1 | WBGene00007604 | View | |
C28C12.4 | C28C12.4 | WBGene00016180 | View | |
C33D9.3 | C33D9.3 | WBGene00007898 | View | |
C44C10.9 | C44C10.9 | WBGene00008089 | View | |
C49A1.10 | C49A1.10 | WBGene00008191 | View | |
daf-7 | B0412.2 | WBGene00000903 |
daf-7 encodes a member of the transforming growth factor beta superfamily that affects dauer larvae formation in a TGF-beta-mediated pathway and also affects egg laying; expressed in the ASI neurons.
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DH11.5 | DH11.5 | WBGene00008438 | View | |
dig-1 | K07E12.1 | WBGene00000998 |
dig-1 was identified in screens for mutations that result in animals with altered gonad morphology; in dig-1 mutants, the gonad is usually displaced anteriorly and sometimes dorsally and animals also display other abnormalities, in neuronal pathfinding, for example, that reflect a more general defect in cell adhesion; dig-1 has been reported to encode a very large cell adhesion molecule defined by the sequences K07E12.1a and K07E12.1b.
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F14F11.2 | F14F11.2 | WBGene00008820 | View | |
F21C10.3 | F21C10.3 | WBGene00017653 | View | |
F40E10.5 | F40E10.5 | WBGene00009573 | View | |
F45D3.2 | F45D3.2 | WBGene00009722 | View | |
F46C8.8 | F46C8.8 | WBGene00018487 | View | |
F53B6.2 | F53B6.2 | WBGene00009958 | View | |
F57B7.1 | F57B7.1 | WBGene00010191 | View | |
F58B4.3 | F58B4.3 | WBGene00010236 | View | |
F59B10.3 | F59B10.3 | WBGene00010319 | View | |
lgc-34 | T27A1.4 | WBGene00020836 | View | |
M04G7.1 | M04G7.1 | WBGene00019772 | View | |
mec-12 | C44B11.3 | WBGene00003175 |
mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons.
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nhl-1 | F54G8.4 | WBGene00003597 |
The nhl-1 gene encodes an RBCC protein, orthologous to the mammalian protein BERP; its C. elegans paralogs include ncl-1 and lin-41.
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nlp-3 | F48C11.3 | WBGene00003741 |
nlp-3 encodes a neuropeptide-like protein of the GFxGF family with similarity to orcokinins, highly conserved peptides native to crustaceans that enhance hindgut contractions; NLP-3 is expressed in neurons in the head, pharynx, and vulva, and in the intestine; the precise role of NLP-3 in nervous system function and development is not yet clear.
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nrx-1 | C29A12.4 | WBGene00007799 | View | |
nsy-4 | Y38F2AL.1 | WBGene00021415 |
Y38F2AL.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; Y38F2AL.1 is worm-specific, with obvious homologs only in C. elegans; Y38F2AL.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.
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oac-46 | T14D7.2 | WBGene00011768 |
T14D7.2 encodes an acyltransferase; large-scale RNAi experiments indicate that T14D7.2 activity is required for egg laying, coordination locomotion, and normal vulval morphology.
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phat-5 | T05B4.11 | WBGene00020242 | View | |
phat-6 | T10B10.6 | WBGene00011683 | View | |
pqn-35 | F35D11.2 | WBGene00004122 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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pqn-48 | K07D4.8 | WBGene00004135 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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ptr-14 | R09H10.4 | WBGene00004228 |
ptr-14 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-14 is weakly required for normal molting from L4 to adult stages; PTR-14 is also required for normal growth to full size and locomotion.
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ptr-8 | F44F4.4 | WBGene00004222 |
ptr-8 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-8 is weakly required for normal molting from L4 to adult stages; PTR-8 is also required for normal growth to full size and locomotion; PTR-8 is expressed in hypodermis.
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rab-3 | C18A3.6 | WBGene00004267 |
rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.
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sem-4 | F15C11.1 | WBGene00004773 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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snt-4 | T23H2.2 | WBGene00004924 | View | |
T07F12.4 | T07F12.4 | WBGene00020324 | View | |
T17H7.7 | T17H7.7 | WBGene00020551 | View | |
T22F7.4 | T22F7.4 | WBGene00020703 | View | |
T25F10.3 | T25F10.3 | WBGene00020806 | View | |
tag-208 | Y45F10D.13 | WBGene00012891 | View | |
unc-82 | B0496.3 | WBGene00006814 | View | |
unc-89 | C09D1.1 | WBGene00006820 |
unc-89 encodes several protein isoforms variably characterized by the presence or absence of SH3, DH, PH, immunoglobulin and myosin light chain kinase (MLCK)-like protein kinase domains; during development, unc-89 is required for proper organization of A bands in striated muscle and thus for fully normal locomotion, pharyngeal muscle contractions, and body size; unc-89 is expressed in body wall muscle, pharyngeal muscle and some cells in the tail; UNC-89 protein isoforms localize to the middle of A-bands, consistent with UNC-89 being an M line component.
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W02F12.2 | W02F12.2 | WBGene00020947 | View | |
W05H12.1 | W05H12.1 | WBGene00012289 | View | |
Y18D10A.8 | Y18D10A.8 | WBGene00012478 | View | |
Y43E12A.2 | Y43E12A.2 | WBGene00012794 | View | |
Y9C2UA.1 | Y9C2UA.1 | WBGene00012421 | View | |
ZC449.1 | ZC449.1 | WBGene00022611 | View | |
ZK131.11 | ZK131.11 | WBGene00013934 | View |