Module
- Number
- 11
- Regulatory Genes
- 3
- Module Genes
- 44
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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H32C10.3 | H32C10.3 | WBGene00019257 | 840 | View | |
R13F6.5 | R13F6.5 | WBGene00020066 | 188 | View | |
rab-11.1 | F53G12.1 | WBGene00004274 | 107 |
rab-11.1 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-11.1 activity is required for completion of the final stages of cytokinesis during early embryogenesis and for efficient uptake of yolk proteins during oocyte development; RAB-11.1 is also required for normal peripheral localization of nuclei in the synctial germ cell in the ovary.
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CLR Predictions
4 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0393.4 | B0393.4 | WBGene00007169 | View | |
C09B9.4 | C09B9.4 | WBGene00015629 | View | |
C09H5.7 | C09H5.7 | WBGene00015661 | View | |
C16D2.1 | C16D2.1 | WBGene00007633 | View | |
C18H7.7 | C18H7.7 | WBGene00015997 | View | |
C27D8.2 | C27D8.2 | WBGene00007778 | View | |
C33F10.8 | C33F10.8 | WBGene00016356 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
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C34D4.2 | C34D4.2 | WBGene00016398 | View | |
C50F4.2 | C50F4.2 | WBGene00008230 |
C50F4.2 encodes a putative 6-phosphofructokinase, paralogous to Y71H10A.1; C50F4.2 is required for fertility, full body size, and normally rapid growth in mass RNAi assays; C50F4.2 transcripts are enriched during spermatogenesis.
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cpb-2 | C30B5.3 | WBGene00000771 |
cpb-2 encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog, expressed specifically in the spermatogenic germ line; CPB-2 is dispensable for oogenesis, in contrast to CPEBs in vertebrates (Xenopus), arthropods (Drosophila), and molluscs (Spisula), which all participate in oogenesis.
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D1081.4 | D1081.4 | WBGene00008382 | View | |
ent-3 | K02E11.1 | WBGene00010510 | View | |
F07F6.1 | F07F6.1 | WBGene00017215 | View | |
F20H11.4 | F20H11.4 | WBGene00017647 | View | |
F22B5.5 | F22B5.5 | WBGene00009043 | View | |
F23C8.8 | F23C8.8 | WBGene00017737 | View | |
F26B1.5 | F26B1.5 | WBGene00017817 | View | |
F36H1.3 | F36H1.3 | WBGene00009492 | View | |
F44G3.7 | F44G3.7 | WBGene00009708 | View | |
F54A3.4 | F54A3.4 | WBGene00018783 |
The F54A3.4 gene encodes a homolog of the human gene CBS, which when mutated leads to homocystinuria (OMIM:236200).
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F55A11.11 | F55A11.11 | WBGene00010082 |
F55A11.11 encodes a member of the histidine phosphatase superfamily orthologous to Bombyx mori ecdysteroid phosphate phosphatase (EPP), human STS1 (OMIM:609201) and human UBASH3A (OMIM:605736); F55A11.11 lacks the consensus sequence for phosphatase activity, and thus is predicted to be catalytically inactive; F55A11.11 is also paralogous to C. elegans C52E4.7, F09C12.8, F53B6.7, and T07F12.1; loss of F55A11.11 activity via large-scale RNAi results in no obvious defects.
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K07A1.4 | K07A1.4 | WBGene00010611 | View | |
K08F8.5 | K08F8.5 | WBGene00010682 | View | |
kin-26 | T06C10.6 | WBGene00002208 | View | |
kin-5 | T13H10.1 | WBGene00002193 |
kin-5 encodes a predicted protein tyrosine kinase that is most closely related to the non-receptor tyrosine kinases Fes/Fps and Fer that contain an SH2 domain and a tyrosine kinase domain (OMIM:190030, murine Fes appears to be required for hemopoietic homeostasis); as loss of kin-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kin-5 in C. elegans development and/or behavior is not yet known.
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klp-17 | W02B12.7 | WBGene00002227 |
klp-17 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; by homology, KLP-17 is predicted to function as a minus-end directed motor; loss of klp-17 activity via RNAi results in embryonic lethality generally at the one- or two-cell stage with disorganized mitotic spindles and polyploid nuclei, suggesting that KLP-17 plays a role in chromosome segregation and germline development; in situ hybridization studies reveal that klp-17 mRNA is localized specifically to cell nuclei during early development, from the one-cell stage of embryogenesis until early larval stages; a klp-17::gfp transgene did not yield detectable GFP expression, but did result in a small percentage of morphologically abnormal males and intersexual animals that grew slowly and died upon reaching maturity, consistent with a role for klp-17 in chromosome dynamics.
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M02B1.4 | M02B1.4 | WBGene00010829 | View | |
R01H2.2 | R01H2.2 | WBGene00019810 | View | |
sfxn-1.1 | AH6.2 | WBGene00007080 | View | |
T01C3.5 | T01C3.5 | WBGene00011322 | View | |
T02E1.7 | T02E1.7 | WBGene00011379 | View | |
T05F1.5 | T05F1.5 | WBGene00011491 | View | |
tag-344 | B0511.4 | WBGene00015230 | View | |
wht-8 | Y47D3A.11 | WBGene00012925 | View | |
Y105C5B.18 | Y105C5B.18 | WBGene00013657 | View | |
Y105E8A.27 | Y105E8A.27 | WBGene00013684 | View | |
Y37D8A.5 | Y37D8A.5 | WBGene00012547 | View | |
Y47G6A.26 | Y47G6A.26 | WBGene00021650 | View | |
Y57G11C.23 | Y57G11C.23 | WBGene00013318 | View | |
ZC250.5 | ZC250.5 | WBGene00045306 | View | |
ZK1128.3 | ZK1128.3 | WBGene00014229 | View | |
ZK354.6 | ZK354.6 | WBGene00022707 | View | |
ZK596.2 | ZK596.2 | WBGene00014007 | View | |
ZK795.2 | ZK795.2 | WBGene00014082 | View |