Module
- Number
- 105
- Regulatory Genes
- 4
- Module Genes
- 40
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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cey-2 | F46F11.2 | WBGene00000473 | 574 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
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zim-1 | T07G12.6 | WBGene00011597 | 330 |
zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
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gla-3 | T02E1.3 | WBGene00011376 | 160 |
gla-3 encodes a TIS11-like protein with two CCCH-like zinc-finger domains that inhibits apoptosis in the germline, and weakly inhibits RAS signalling in vulval development along with RAS-induced muscle protein degradation; GLA-3 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; gla-3 is expressed in the germline of L4 larvae and adults, and interacts with mpk-1 both genetically and physically; gla-3 requires core apoptotic proteins (CED-3 and CED-4) for its excess apoptotic mutant phenotype, but not others (CEP-1, CLK-2, or HUS-1) required for DNA damage-induced apoptosis; gla-3 mutants have increased germline apoptosis and reduced brood size due to defective pachytene exit from meiosis I, and also show weak enhancment of the multivulva phenotype of let-60(gf) or lip-1(zh15) mutations; gla-3 mutants have temperature-sensitive progressive muscle dystrophy, consistent with hyperactivation of the RAS/MAPK pathway in muscle cells; gla-3(RNAi) hermaphrodites display elevated levels of physiological germline apoptosis, independent of CEP-1.
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Y62E10A.14 | Y62E10A.14 | WBGene00013380 | 120 | View |
CLR Predictions
209 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C01B10.9 | C01B10.9 | WBGene00015283 | View | |
C16A3.2 | C16A3.2 | WBGene00015807 | View | |
C16C8.12 | C16C8.12 | WBGene00015850 | View | |
C30F12.2 | C30F12.2 | WBGene00016261 | View | |
C32A3.3 | C32A3.3 | WBGene00007860 | View | |
C35E7.8 | C35E7.8 | WBGene00016460 | View | |
dnj-26 | Y39C12A.8 | WBGene00001044 |
This gene encodes a protein containing a DnaJ ('J') domain.
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dnj-28 | Y54E10BL.4 | WBGene00001046 |
This gene encodes a protein containing a DnaJ ('J') domain.
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F01G4.3 | F01G4.3 | WBGene00008502 | View | |
F34D10.4 | F34D10.4 | WBGene00009374 | View | |
F55A12.10 | F55A12.10 | WBGene00018867 |
F55A12.10 encodes a RING finger protein orthologous to budding yeast Cst9p (meiotically expressed) and human RNF212 (associated with varying recombination rate); F55A12.10 is paralogous to ZHP-3, D1081.9, and Y39B6A.16; F55A12.10 has no obvious function in mass RNAi assays.
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F58G1.1 | F58G1.1 | WBGene00010263 | View | |
fbf-1 | H12I13.4 | WBGene00001401 |
fbf-1 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
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fbf-2 | F21H12.5 | WBGene00001402 |
fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
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fbxa-197 | T06C12.4 | WBGene00011513 | View | |
him-5 | D1086.4 | WBGene00001864 |
him-5 was identified in screens for genes that when mutated resulted in an increased frequency of X chromosome nondisjunction and thus, an increased frequency of genotypically XO males in self-fertile populations; him-5 functions in X chromosome dynamics by regulating the number and distribution of X chromosome pairing events; the molecular identity of him-5 is not yet known.
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K04C1.5 | K04C1.5 | WBGene00010555 | View | |
K12H4.2 | K12H4.2 | WBGene00019677 | View | |
klp-18 | C06G3.2 | WBGene00002228 |
klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
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pgl-2 | B0523.3 | WBGene00003993 |
pgl-2 encodes a novel protein of 532 amino acids that, in C. elegans, is one of three PGL protein family members; PGL-2 associates with P granules during postembryonic development; PGL-2 interacts with PGL-1, an additional P granule component, in yeast two-hybrid assays, but neither protein is required for proper localization of the other.
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R05D3.1 | R05D3.1 | WBGene00019876 | View | |
R05H10.2 | R05H10.2 | WBGene00011043 | View | |
rab-30 | Y45F3A.2 | WBGene00004282 |
rab-30 encodes a rab related protein of the Ras GTPase superfamily.
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spd-3 | H34C03.1 | WBGene00004954 | View | |
T24C4.5 | T24C4.5 | WBGene00020761 | View | |
T26A5.2 | T26A5.2 | WBGene00020819 | View | |
tag-347 | C25G4.4 | WBGene00007732 | View | |
tdc-1 | K01C8.3 | WBGene00006562 | View | |
tpk-1 | ZK637.9 | WBGene00014027 | View | |
W02D9.3 | W02D9.3 | WBGene00012209 | View | |
wdfy-2 | D2013.2 | WBGene00008402 |
wdfy-2 encodes a WD40- and FYVE-domain containing protein that is orthologous to mammalian WDFY2; WDFY-2 is one of twelve C. elegans FYVE-domain-containing proteins; wdfy-2 activity is essential for wild-type levels of endocytosis.
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Y105E8A.20 | Y105E8A.20 | WBGene00013678 | View | |
Y39G10AR.7 | Y39G10AR.7 | WBGene00021465 | View | |
Y44F5A.1 | Y44F5A.1 | WBGene00012858 | View | |
Y55F3AM.11 | Y55F3AM.11 | WBGene00021928 | View | |
Y55F3AM.3 | Y55F3AM.3 | WBGene00021921 | View | |
Y57A10A.5 | Y57A10A.5 | WBGene00013250 | View | |
zim-1 | T07G12.6 | WBGene00011597 |
zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
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zim-3 | T07G12.11 | WBGene00011601 |
zmp-3 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1/-2, and C02F5.12; ZIM-3 is specifically required for homolog pairing, synapsis, and segregation of chromosomes I and IV during meiosis; zim-3(tm2303) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes I and IV; ZIM-3 associates with the right end of chromosome I and the left end of chromosome IV, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-3 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-3 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-3 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
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ZK20.4 | ZK20.4 | WBGene00013925 | View |