Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

pdi-1  

Sequence Name

C14B1.1  

WB ID

WBGene00003962  

Description

pdi-1 encodes a protein disulfide isomerase; loss of function mutations in pdi-1 result in no obvious abnormalities, but animals triply mutant for three C. elegans PDI's, encoded by pdi-1, pdi-2, and pdi-3, display embryonic lethality characterized by loss of vermiform morphology after elongation, suggesting that the pdi genes function redundantly in embryonic morphogenesis; PDI-1 exhibits protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity in vitro; pdi-1::lacZ reporter fusions are expressed in the hypodermis.