Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

mps-1  

Sequence Name

C29F5.4  

WB ID

WBGene00003403  

Description

mps-1 encodes single-pass transmembrane proteins that are related to the vertebrate KCNE proteins, also known as MinK-related peptides (MiRPs) that associate with, and regulate, pore-forming ion channels; mps-1 is required for the normal function of several neurons and thus for normal body touch sensation, chemotaxis to select molecules, osmotic avoidance, and nose-touch; when assayed in ASER neurons or in tissue culture cells coexpressing C. elegans KVS-1, MPS-1 is able to alter the activity of this potassium-selective channel, suggesting that MPS-1 functions in vivo to regulate KVS-1 activity in neurons in which the two proteins are coexpressed; mps-1 reporter fusions are expressed in the vulva and in several chemosensory and mechanosensory neurons, including the ADF neuron.