Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

T21H8.1  

Sequence Name

T21H8.1  

WB ID

WBGene00011904  

Description

T21H8.1 encodes the C. elegans ortholog of human beta-liprin, a coiled-coil domain-containing protein that interacts with alpha-liprin, a transmembrane protein-tyrosine phosphatase-interacting protein; as loss of T21H8.1 activity via large-scale RNAi results in no obvious abnormalities, the precise role of T21H8.1 in C. elegans development and/or behavior is not yet known; however, by virtue of its similarity to human beta-liprin, the protein product of T21H8.1 is predicted to function as part of a protein complex that localizes to focal adhesions and regulates cell-extracellular matrix interactions; a T21H8.1 promoter::GFP fusion construct directs expression in pharyngeal and body wall muscles, and in regions adjacent to the dorsal and ventral nerve cords; expression in the pharynx is particularly strong in the posterior bulb.