InterPro domain: IPR045151
General Information
- Identifier IPR045151
- Description DDB1- and CUL4-associated factor 8-like
- Number of genes 435
- Gene duplication stats Loading...
Abstract
This entry represents a group of WD and tetratricopeptide repeats proteins, including DCAF5/6/8 and DCAF8L1/DCAF8L2/WDTC1 from humans. They may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex [ 1 ].
Proteins in this entry also include protein ALTERED SEED GERMINATION 2 (ASG2) from Arabidopsis. It is a negative regulator of ABA signalling [ 2 ].
1. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 443, 590-3
2. ASG2 is a farnesylated DWD protein that acts as ABA negative regulator in Arabidopsis. Plant Cell Environ 39, 185-98
Species distribution
Gene table
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