InterPro domain: IPR045151

General Information

  • Identifier IPR045151
  • Description DDB1- and CUL4-associated factor 8-like
  • Number of genes 435
  • Gene duplication stats Loading...

Abstract

This entry represents a group of WD and tetratricopeptide repeats proteins, including DCAF5/6/8 and DCAF8L1/DCAF8L2/WDTC1 from humans. They may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex [ 1 ].

Proteins in this entry also include protein ALTERED SEED GERMINATION 2 (ASG2) from Arabidopsis. It is a negative regulator of ABA signalling [ 2 ].


1. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 443, 590-3
2. ASG2 is a farnesylated DWD protein that acts as ABA negative regulator in Arabidopsis. Plant Cell Environ 39, 185-98

Species distribution

Gene table