InterPro domain: IPR045141

This entry includes NAA60 from animals and MCC1 from Arabidopsis. NAA60 (also known as NatF) is an N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N termini facing the cytosol. It is localized in the Golgi apparatus [ 1 ]. In Drosophila, NAA60 knockdown cells shows chromosomal segregation defects [ 2 ].

MCC1 may be a histone acetyltransferase involved in plant meiosis [ 3 ].

1. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. Cell Rep 10, 1362-74
2. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet 7, e1002169
3. Histone hyperacetylation affects meiotic recombination and chromosome segregation in Arabidopsis. Plant J 62, 796-806