InterPro domain: IPR045124

This entry includes protein suppressor of sable (also known as Su(s)) from flies and related proteins from eukaryotes. They contain closely related CCCH zinc finger (ZF) motifs. Su(s) is a nuclear RNA-binding protein that inhibits the accumulation of certain aberrant mRNAs [ 1 ]. It has been shown to interact with Wdr82, and together they inhibit Pol II elongation through Hsp70-alphabeta elements [ 2 ].

1. Drosophila suppressor of sable protein [Su(s)] promotes degradation of aberrant and transposon-derived RNAs. Mol Cell Biol 29, 5590-603
2. Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination. RNA 22, 139-54