InterPro domain: IPR045123

In humans, the METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis [ 1 , 2 , 3 , 4 , 5 , 6 ]. This entry also includes Kar4 from budding yeasts. Kar4 is a phosphoprotein required for expression of karyogamy-specific genes during mating and that it also acts during mitosis and meiosis [ 7 ].

1. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 10, 93-5
2. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 24, 177-89
3. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature 518, 560-4
4. Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex. RNA 24, 499-512
5. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol Cell 63, 306-317
6. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature 534, 575-8
7. Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Mol. Cell. Biol. 27, 818-29