InterPro domain: IPR045120
General Information
- Identifier IPR045120
- Description SUN domain-containing Suco/Slp1-like
- Number of genes 276
- Gene duplication stats Loading...
- Associated GO terms GO:0016020
Abstract
This entry represents a group of SUN domain-containing proteins, including Suco (SUN domain-containing ossification factor) from animals and Slp1 from yeasts. SUN-domain containing proteins contain three structural features: a transmembrane, a coiled-coil, and a SUN domain.
Suco regulates type I collagen synthesis in osteoblasts during their postnatal maturation [ 1 ]. Slp1 is required for localization of MPS3 (a SUN domain-containing protein) to the nuclear envelope [ 2 ].
1. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol 189, 511-25
2. Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. G3 (Bethesda) 2, 1703-18