InterPro domain: IPR045112

Peter Pan (PPAN) was initially identified in Drosophila melanogaster. PPAN is highly conserved and essential for maintaining growth and survival [ 1 ]. Human PPAN localizes to nucleoli and to mitochondria. It can shuttle between the nucleus and the cytoplasm in response to nucleolar stress and apoptosis induction [ 2 ]. PPAN knockdown has been linked to mitochondrial damage and stimulates autophagy [ 3 ]. The yeast homologues of PPAN, Ssf1 and Ssf2, are nucleolar ribosome biogenesis factors required for maturation of the large ribosomal subunit [ 4 ].

1. Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth. Mol Biol Cell 10, 1733-44
2. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. J Biol Chem 290, 10905-18
3. Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux. Cells 8
4. Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. FEMS Yeast Res. 3, 35-43