InterPro domain: IPR045108

General Information

  • Identifier IPR045108
  • Description Thioredoxin domain-containing protein 17-like
  • Number of genes 118
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004601  

Abstract

This entry represents a group of thioredoxin domain-containing proteins, including TXNDC17 from animals, SPBC21C3.12c from fission yeasts and AtClot from Arabidopsis. TXNDC17, also known as TRP14, is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways. TXNDC17 has been shown to efficiently reduce l-cystine and can directly reactivate oxidized protein-tyrosine phosphatase PTP1B [ 1 ].


1. Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways. Br J Pharmacol 176, 544-553

Species distribution

Gene table