InterPro domain: IPR045106

Budding yeast Kti12 associates with Elongator complex, a six-subunit histone acetyltransferase complex that functions with the elongating form of RNA polymerase II during transcription [ 1 ]. It is not a structural subunit but may play a regulatory role in Elongator function [ 2 ]. It has been shown that Kti12 is associated with chromatin throughout the genome, even in non-transcribed regions and in the absence of Elongator [ 3 ]. It is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA [ 3 ].

1. Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. J. Biol. Chem. 280, 19454-60
2. Molecular analysis of KTI12/TOT4, a Saccharomyces cerevisiae gene required for Kluyveromyces lactis zymocin action. Mol Microbiol 43, 783-91
3. An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11, 424-36