InterPro domain: IPR045100

This domain can be found in terminal uridylyltransferases and poly(A) RNA polymerases. Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay [ 1 , 2 ]. GLD2 is a cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail [ 3 ].

1. Uridylation by TUT4 and TUT7 marks mRNA for degradation. Cell 159, 1365-76
2. Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression. Nat Commun 10, 1960
3. Mammalian GLD-2 homologs are poly(A) polymerases. Proc Natl Acad Sci U S A 101, 4407-12