InterPro domain: IPR045068
General Information
- Identifier IPR045068
- Description BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1/2/3
- Number of genes 234
- Gene duplication stats Loading...
Abstract
This entry represents a group of BTB/POZ domain-containing proteins, such as BACURD1-3 from humans. They act as the substrate-specific adapters of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of RhoA, leading to its degradation by the proteasome [ 1 ]. This entry also includes EAP3 from Arabidopsis. The BTB/POZ domain of EAP3 displays poor conservation of the residues required for CUL3 binding and is not likely to function as an E3 ligase adaptor [ 2 ].
1. Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell 35, 841-55
2. Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility. Nat Plants 3, 854-858