InterPro domain: IPR045065

Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos) [ 1 ]. Exportin-5 yeast homologue, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4 [ 2 , 3 , 4 ]. Its Arabidopsis homologue, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs) [ 5 ].

This entry includes exportin-1/5 from eukaryotes.Exportin-1, also known as CRM1, is a nuclear export receptor that have been shown to be involved in U3 snoRNA transport from Cajal bodies to nucleoli [ 6 ]. It also controls the composition of many nucleoplasmic complexes [ 7 ].

1. Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J. Cell Biol. 156, 53-64
2. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J. Cell Biol. 152, 729-40
3. Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Mol. Cell. Biol. 23, 3126-40
4. Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5. Biochim. Biophys. Acta 1823, 959-70
5. Nuclear processing and export of microRNAs in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 102, 3691-6
6. PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli. Mol Cell 16, 777-87
7. CRM1 plays a nuclear role in transporting snoRNPs to nucleoli in higher eukaryotes. Nucleus 3, 132-7