InterPro domain: IPR045057

This family represents Gcn5-related N-acetyltransferases (GNAT) ([intenz:2.3.1.-]), which catalyse the transfer of the acetyl from the CoA donor to a primary amine of the acceptor and share a domain composed of four conserved sequence motifs A-D [ 1 , 2 , 3 , 4 ]. It includes Protein NATD1 from animals, Acetyltransferase At1g77540 from Arabidopsis [ 5 ] and the uncharacterised protein YjdJ from E.coli. At1g77540 is a H3/H4 histone acetyltransferase [ 6 ].

1. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem. Sci. 22, 154-5
2. GCN5-related N-acetyltransferases: a structural overview. Biochemistry 29, 81-103
3. Structure of an acetyl-CoA binding protein from Staphylococcus aureus representing a novel subfamily of GCN5-related N-acetyltransferase-like proteins. PLoS ONE 9, 7-20
4. Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. null 8, e70369
5. Structure of Arabidopsis thaliana At1g77540 protein, a minimal acetyltransferase from the COG2388 family. J. Struct. Funct. Genomics 45, 14325-36