InterPro domain: IPR045056

General Information

  • Identifier IPR045056
  • Description Nucleolar protein Nop56/Nop58

Abstract

This entry includes a group of pre-RNA processing ribonucleoproteins (RNPs), including Nop56/Nop58 from animals and their homologue, Nop5, from archaea. Proteins in this family contains the Nop domain, which is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively alpha-helical [ 1 , 2 ]. Nop56 and Nop58 are components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles [ 3 , 4 ].


1. Structure and function of archaeal box C/D sRNP core proteins. Nat. Struct. Biol. 10, 256-63
2. Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science 316, 115-20
3. Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. J Biol Chem 278, 34309-19
4. Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis. Mol Cell Biol 29, 4971-81

Species distribution

Gene table