InterPro domain: IPR045048

F-box only protein 31 is a component of the SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognises phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest [ 1 , 2 ].

HAWAIIAN SKIRT (HWS; At3G61590) is a F-box dependent factor involved in miRNA function [ 3 ]. Loss of function of HWS exhibits pleiotropic phenotypes including sepal fusion [ 4 ].This entry represents a group of F-box only proteins, including FBXO31/39 from humans and HAWAIIAN SKIRT (At3g61590) from Arabidopsis.

1. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res. 65, 11304-13
2. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459, 722-5
3. A Role for the F-Box Protein HAWAIIAN SKIRT in Plant microRNA Function. Plant Physiol 176, 730-741
4. The Arabidopsis thaliana F-box gene HAWAIIAN SKIRT is a new player in the microRNA pathway. PLoS One 12, e0189788