InterPro domain: IPR045047

Ard1 and Nat1 form a stable N-terminal acetyltransferase complex and are conserved from yeast to human [ 1 ]. This entry represents Ard1, which is the catalytic subunit. The ARD1-NAT1 complex mediates N-terminal acetylation of nascent polypeptides that emerge from ribosomes after translation [ 2 ].

1. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 11, 2087-93
2. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A 106, 8157-62