InterPro domain: IPR045038

Gamma-glutamyl cyclotransferases (GGCTs) are ubiquitous enzymes found in bacteria, plants, and metazoans. This family includes AIG2 proteins from Arabidopsis, which exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2 [ 1 ]. Its structure consists of a five-stranded beta-barrel surrounded by two alpha-helices and a small beta-sheet. A long flexible alpha-helix protrudes from the structure at the C-terminal end. Conserved residues in a hydrophilic cavity, which are able to bind small ligands, may act as an active site in AIG2-like proteins [ 2 ].

1. Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes. Plant Cell 8, 241-9
2. Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62, 490-3