InterPro domain: IPR045017
General Information
- Identifier IPR045017
- Description Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
- Number of genes 195
- Gene duplication stats Loading...
- Associated GO terms GO:0009062 GO:0008670
Abstract
This entry includes peroxisomal 2,4-dienoyl CoA reductases (pDCR) from eukaryotes and its homologues from bacteria and archaea. DCR is an auxiliary enzyme of fatty acid beta-oxidation. Proteins in this family belong to the short chain dehydrogenase/reductase (SDR) superfamily. They share a highly conserved Rossmann fold used for binding cofactors like NADH or NADPH. Unlike other members belonging to the SDR family, catalysis by pDCR does not involve a tyrosine-serine pair. Instead, a catalytically critical aspartate, together with an invariant lysine, polarizes a water molecule to donate a proton for the formation of the product [ 1 ].
1. Studies of Human 2,4-Dienoyl CoA Reductase Shed New Light on Peroxisomal β-Oxidation of Unsaturated Fatty Acids. J. Biol. Chem. 287, 28956-65