InterPro domain: IPR045008

This entry represents a group of acyl-CoA dehydrogenases from bacteria and plants, including acyl-coenzyme A oxidase 4 (ACX4) from Arabidopsis. ACX4 catalyses the desaturation of short-chain acyl-CoAs to 2-trans-enoyl-CoAs in plant peroxisomes [ 1 , 2 ]. It is essential for embryo development [ 3 ] and is required for nuclear histone acetylation and DNA demethylation at some endogenous genomic loci [ 4 ].

1. A novel acyl-CoA oxidase that can oxidize short-chain acyl-CoA in plant peroxisomes. J Biol Chem 274, 12715-21
2. Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in beta-oxidation. Plant J 41, 859-74
3. Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development. J. Biol. Chem. 278, 21370-7
4. Peroxisomal β-oxidation regulates histone acetylation and DNA methylation in Arabidopsis. Proc Natl Acad Sci U S A 116, 10576-10585