InterPro domain: IPR044963
General Information
- Identifier IPR044963
- Description Succinate dehydrogenase subunit 4, mitochondrial
- Number of genes 66
- Gene duplication stats Loading...
- Associated GO terms GO:0005749 GO:0006099 GO:0006121 GO:0005743
Abstract
Complex II [succinate dehydrogenase (succinate-ubiquinone oxidoreductase); SDH] is the only enzyme shared by both the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria. SDH is a heterotetrameric protein complex, anchored to the inner mitochondrial membrane by two integral membrane proteins, SDH3 and SDH4. The SDH3/SDH4 dimer binds to subunit SDH2, which contains three iron-sulfur (Fe-S) clusters and is assembled with the catalytic subunit SDH1 [ 1 ]. These membrane proteins (SDH1-4) are structurally and evolutionarily related, and include three membraneâ€spanning helices each, forming a conserved sixâ€helix bundle that binds a heme group [ 2 ].
This entry represents succinate dehydrogenase 4 (SDH4) from plants.
1. The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana. Plant Mol Biol 50, 725-34
2. Mitochondrial complex II of plants: subunit composition, assembly, and function in respiration and signaling. Plant J 98, 405-417