InterPro domain: IPR044917
General Information
- Identifier IPR044917
- Description DNA-directed primase/polymerase protein
- Number of genes 151
- Gene duplication stats Loading...
- Associated GO terms GO:0003896 GO:0003887 GO:0042276
Abstract
PRIMPOL has both DNA polymerase and DNA/RNA primase activities. It is involved in downstream repriming of stalled forks during both nuclear and mitochondrial DNA replication. It pays an important part in DNA damage tolerance [ 1 ]. It is predicted to possess an archaeo-eukaryotic primase and a UL52-like zinc finger domain [ 2 , 3 ]. The primase activity of PRIMPOL is essential for many functions in the nucleus. However, the role of PRIMPOL polymerase activity is still unclear, as PRIMPOL synthesizes DNA with limited processivity, rarely incorporating more than four nucleotides on an undamaged template [ 4 ].
1. PRIMPOL ready, set, reprime! Crit Rev Biochem Mol Biol 56, 17-30
2. Structure and mechanism of human PrimPol, a DNA polymerase with primase activity. Sci Adv 2, e1601317
3. Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Res 42, 5830-45
4. To skip or not to skip: choosing repriming to tolerate DNA damage. Mol Cell 81, 649-658