InterPro domain: IPR044847

This entry represents KANADI (Kan), a family of plant transcription factors. In Arabidopsis, there are four Kan members, KAN1-4, which are expressed in the phloem. KAN1 may control cambium activity through acting on auxin transport by inhibiting PIN gene expression [ 1 ]. KAN1 has also been shown to repress the transcription of AS2 (ASYMMETRIC LEAVES2) in abaxial cells and regulate adaxial-abaxial polarity [ 2 ]. It also plays a role in lateral root formation and development [ 3 ]. This entry also includes RL9 (also known as SHALLOT-LIKE1, SLL1) from Oryza sativa subsp. japonica. RL9 controls rice leaf rolling by regulating leaf abaxial cell development [ 4 ].

1. Interplay of auxin, KANADI and Class III HD-ZIP transcription factors in vascular tissue formation. Development 137, 975-84
2. KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2. Proc Natl Acad Sci U S A 105, 16392-7
3. Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development. Plant Physiol 135, 2261-70
4. SHALLOT-LIKE1 is a KANADI transcription factor that modulates rice leaf rolling by regulating leaf abaxial cell development. Plant Cell 21, 719-35