InterPro domain: IPR044833
General Information
- Identifier IPR044833
- Description Protein WVD2-like 4/5/6
- Number of genes 413
- Gene duplication stats Loading...
- Associated GO terms GO:0008017
Abstract
In animals, Targeting Protein for Xklp2 (TPX2) is critical for mitotic spindle assembly. It has a highly conserved TPX2 central domain, an Aurora-A binding domain and a TPX2_C domain that contains a conserved pentapeptide KLEEK motif. However, in plants besides the TPX2 homologue (with three domains), several proteins were found with only the TPX2_C domain. This group of TPX2_C domain only proteins in plants has been named as WDL (or WVD2-like) proteins, as the first identified member is known as WVD2. These WDL proteins bind to microtubules; however, they have lost the function of targeting Xklp2 and were found to play roles in plant development and responses to environment cues [ 1 , 2 ].This entry includes WDL4/5/6 from Arabidopsis.
1. WVD2 and WDL1 modulate helical organ growth and anisotropic cell expansion in Arabidopsis. Plant Physiol. 131, 493-506
2. Ethylene Regulates the Arabidopsis Microtubule-Associated Protein WAVE-DAMPENED2-LIKE5 in Etiolated Hypocotyl Elongation. Plant Physiol 169, 325-37