InterPro domain: IPR044832

This family represents a group of plant asparagine-rich proteins containing a Development and Cell Death (DCD) domain which is present in proteins with different architectures, some of them contain additional recognisable motifs, like the KELCH repeats or the ParB domain. They are involved in stress signalling pathway that mediate cell death in response to endoplasmic reticulum (ER) stress and osmotic stress [ 1 , 2 ]. Including in this entry are soybean DCD domain-containing proteins NRP-A/B, NRP from Arabidopsis and B2 protein from carrot. NRP was first found in soybean as a component of the early pathogen response and was induced under ER stress [ 3 , 3 ]. In Arabidopsis, NRP contributes to the initial phase of responses to abiotic and biotic stress signals. It binds the phytochrome-associated protein phosphatase FYPP3 and facilitates FYPP3 degradation to promote abscisic acid (ABA) response, a regulatory circuit which links intracellular trafficking with ABA signaling [ 4 , 4 ].

1. A new branch of endoplasmic reticulum stress signaling and the osmotic signal converge on plant-specific asparagine-rich proteins to promote cell death. J Biol Chem 283, 20209-19
2. Functional and regulatory conservation of the soybean ER stress-induced DCD/NRP-mediated cell death signaling in plants. BMC Plant Biol 16, 156
3. The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2. J. Exp. Bot. 68, 3427-3440
4. The Asparagine-Rich Protein NRP Facilitates the Degradation of the PP6-type Phosphatase FyPP3 to Promote ABA Response in Arabidopsis. Mol Plant 11, 257-268