InterPro domain: IPR044820

This entry represents a group of plant ADP-ribosylation factor GTPase-activating proteins, including AGD14 from Arabidopsis. Arabidopsis contains 15 proteins with ArfGAP domains (AGDs) which can be divided into four distinct classes based on phylogenetic analysis. AGD14 belongs to class 4 together with AGD15 in which the AGD comprises almost the entire open reading frames of these proteins. In AtAGD14, the AGD is followed by an apparent membrane-spanning alpha-helix, suggesting this ArfGAP could be an integral membrane protein [ 1 ].

1. Analysis of the small GTPase gene superfamily of Arabidopsis. Plant Physiol 131, 1191-208