InterPro domain: IPR044818
General Information
- Identifier IPR044818
- Description Transcription factor ILR3-like
- Number of genes 542
- Gene duplication stats Loading...
- Associated GO terms GO:0055072 GO:0003700 GO:0006355 GO:0046983
Abstract
This family represents a group of plant transcription factors, including ILR3 (also known as AtbHLH105) and its closest homologues bHLH34, bHLH104 and bHLH115 from Arabidopsis [ 1 ]. These transcription factors can form homo- and heterodimers and are involved in the positive regulation of Fe homeostasis by directly activating bHLH38, bHLH39, bHLH100, and bHLH101 expression. ILR3 can also act as a transcriptional repressor when interacting with POPEYE (PYE)/bHLH47, which plays a negative role in the Fe deficiency responses [ 2 , 2 ]. bHLH34 and bHLH104 are also involved in the glucose-mediated and ABA signalling pathways [ 3 ].
1. The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis. Plant Cell 32, 508-524
2. A key gene bHLH115 in iron homeostasis: comprehensive bioinformatics analyses in Arabidopsis, tomato, rice, and maize. Biometals 32, 641-656
3. A basic helix-loop-helix 104 (bHLH104) protein functions as a transcriptional repressor for glucose and abscisic acid signaling in Arabidopsis. Plant Physiol Biochem 136, 34-42