InterPro domain: IPR044796
General Information
- Identifier IPR044796
- Description Protein MLN51 homolog, plant
- Number of genes 213
- Gene duplication stats Loading...
- Associated GO terms GO:0035145 GO:0003729 GO:0006397
Abstract
The exon-junction complex (EJC) is involved in post-transcriptional regulation of mRNA. The core of EJC consists of Y14, Magoh, MLN51 and eIF4AIII, a DEAD-box RNA helicase. EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery, and its core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism. Human MLN51 has been shown to stimulate the ATPase activity of eIF4AIII [ 1 ]. This entry represents the plant MLN51 homologues. Similar to animal MLN51, Arabidopsis MLN51 is also a core component of the plant EJC [ 2 ].
1. MLN51 stimulates the RNA-helicase activity of eIF4AIII. PLoS ONE 2, e303
2. Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia. Plant Cell 21, 1592-606