InterPro domain: IPR044792

This entry includes transcript antisense to ribosomal RNA protein 1 (TAR1) from Saccharomyces cerevisiae and Kluyveromyces lactis [ 1 ]. TAR1 might be involved in regulation of respiratory metabolism expression as it is induced under respiratory conditions to maintain oxidative phosphorylation capacity. Its levels in mitochondria are tightly controlled and usually low. It is down-regulated to manage oxidative stress when respiration is defective [ 2 ]. This entry also includes uncharacterised plant proteins.

1. A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA. Genes Dev 16, 2755-60
2. Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction. Curr Genet 54, 83-94