InterPro domain: IPR044780
General Information
- Identifier IPR044780
- Description Heh2/Src1-like
- Number of genes 113
- Gene duplication stats Loading...
- Associated GO terms GO:0005637 GO:0003682
Abstract
This family includes inner membrane proteins from plants and fungi, including Heh2/Src1 from budding yeasts and Lem2/Mug61 from fission yeasts [ 1 , 2 , 3 , 4 ]. These proteins contain the N-terminal HEH/LEM domain that anchors the chromatin to the nuclear periphery, and a MSC (MAN1/Src1Câ€terminal) domain in their C-terminal region. They are involved in meiosis, required for the correct meiotic chromosome segregation.
1. Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions. Genes Cells 21, 812-32
2. A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events. Curr. Biol. 15, 2056-62
3. High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I. Cell Cycle 9, 1802-8
4. Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast. Genes Cells 23, 122-135