InterPro domain: IPR044779

SSXT (also known as SS18) appears to function synergistically with RBM14 as a transcriptional coactivator [ 1 ].

The SSXT protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2 [ 2 ].

The SS18 family also includes SS18-like proteins 1 and 2, and GRF1-interacting factors from plants [ 3 ]. SS18-like protein 1 is a transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons [ 4 , 5 ].

1. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology 146, 3892-9
2. The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery. Oncogene 21, 5791-6
3. The Arabidopsis GRF-INTERACTING FACTOR gene family performs an overlapping function in determining organ size as well as multiple developmental properties. Plant Physiol. 151, 655-68
4. Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Science 303, 197-202
5. A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60, 775-87