InterPro domain: IPR044773

General Information

  • Identifier IPR044773
  • Description DDX18/Has1, DEAD-box helicase domain
  • Number of genes 172
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005524   GO:0003724  

Abstract

This entry represents the DEAD-box helicase domain found in DDX18 from animals and Has1 from fungi. This domain contains the ATP-binding region. Has1 is a ATP-dependent RNA helicase involved in 40S and 60S ribosomal subunit biogenesis [ 1 , 2 ]. DDX18 is a putative RNA-dependent helicase which is activated by Myc protein [ 3 ].


1. Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Mol Microbiol 52, 141-58
2. Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits. Nucleic Acids Res 41, 7889-904
3. Cellular DEAD-box RNA helicase 18 (DDX18) Promotes the PRRSV Replication via Interaction with Virus nsp2 and nsp10. Virus Res 238, 204-212

Species distribution

Gene table