InterPro domain: IPR044763

General Information

  • Identifier IPR044763
  • Description Ded1/Dbp1, DEAD-box helicase domain
  • Number of genes 342
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005524   GO:0003724  

Abstract

This entry represents the DEAD/DEAH box helicase domain found in Ded1 and its paralog, Dbp1, from yeasts, which contains the ATP-binding region. Ded1 and Dbp1 are ATP-dependent DEAD-box RNA helicases involved in eIF4F-dependent 48S translation preinitiation complex (PIC) assembly [ 1 , 2 ]. This entry also includes Drosophila melanogaster Vasa, which is essential for development [ 3 ].


1. Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner. Elife 7
2. Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo. Nucleic Acids Res 47, 8785-8806
3. Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell 125, 287-300

Species distribution

Gene table