InterPro domain: IPR044763
General Information
- Identifier IPR044763
- Description Ded1/Dbp1, DEAD-box helicase domain
- Number of genes 342
- Gene duplication stats Loading...
- Associated GO terms GO:0005524 GO:0003724
Abstract
This entry represents the DEAD/DEAH box helicase domain found in Ded1 and its paralog, Dbp1, from yeasts, which contains the ATP-binding region. Ded1 and Dbp1 are ATP-dependent DEAD-box RNA helicases involved in eIF4F-dependent 48S translation preinitiation complex (PIC) assembly [ 1 , 2 ]. This entry also includes Drosophila melanogaster Vasa, which is essential for development [ 3 ].
1. Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner. Elife 7
2. Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo. Nucleic Acids Res 47, 8785-8806
3. Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell 125, 287-300