InterPro domain: IPR044762

General Information

  • Identifier IPR044762
  • Description DHX8/ Prp22, DEXH-box helicase domain

Abstract

DHX8 and its homologue, Prp22, act late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes [ 1 , 2 ]. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding [ 3 ].

This entry represents the ATP-binding domain found in DHX8 from animals and Prp22 from yeasts.


1. An Atomic Structure of the Human Spliceosome. Cell 169, 918-929.e14
2. Genome-wide analysis of pre-mRNA splicing: intron features govern the requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae and Schizosaccharomyces pombe. J. Biol. Chem. 279, 52437-46
3. From unwinding to clamping - the DEAD box RNA helicase family. Nat. Rev. Mol. Cell Biol. 12, 505-16

Species distribution

Gene table