InterPro domain: IPR044719

This entry includes a group of NAD(P)-binding domain-containing proteins from plants and Cyanobacteria, including TIC62 from Arabidopsis. TIC62 is part of the Tic complex (a redox regulon) involved in translocation of nuclear-encoded preproteins across the inner envelope of chloroplasts [ 1 ]. TIC62 binds to ferredoxin-NADP(H) oxidoreductase (FNR) and acts as a redox sensor of the complex [ 2 ].

1. Protein import into chloroplasts involves redox-regulated proteins. EMBO J 21, 6136-45
2. Arabidopsis Tic62 and ferredoxin-NADP(H) oxidoreductase form light-regulated complexes that are integrated into the chloroplast redox poise. Plant Cell 21, 3965-83