InterPro domain: IPR044717

General Information

  • Identifier IPR044717
  • Description Nicotinamidase 1
  • Number of genes 203
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008936   GO:0019365  

Abstract

This entry represents a group of amidohydrolases from plants and bacteria, including AtNIC1 from Arabidopsis. AtNIC1 catalyses the deamidation of nicotinamide, an early step in the NAD+ salvage pathway. It prevents the accumulation of intracellular nicotinamide, a known inhibitor of poly(ADP-ribose) polymerases (PARP enzymes) [ 1 ].


1. Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis. Plant J 49, 1020-9

Species distribution

Gene table