InterPro domain: IPR044709
General Information
- Identifier IPR044709
- Description Microtubule-binding protein TANGLED1
- Number of genes 151
- Gene duplication stats Loading...
- Associated GO terms GO:2000694 GO:0008017
Abstract
TANGLED1 (TAN1) is a microtubule-binding protein that localizes to the division site and mitotic microtubules and plays a critical role in division plane orientation in plants [ 1 ]. It acts as a component of a cortical guidance cue that remains behind when the preprophase band (PPB) is disassembled and directs the expanding phragmoplast to the former PPB site during cytokinesis [ 2 , 3 , 4 , 5 ]. It has been shown to mediate microtubule zippering or end-on microtubule interactions, depending on their contact angle [ 6 ].
1. TANGLED1 mediates microtubule interactions that may promote division plane positioning in maize. J Cell Biol 219, 1875-88
2. Arabidopsis TANGLED identifies the division plane throughout mitosis and cytokinesis. Curr Biol 17, 1827-36
3. Division Plane Orientation Defects Revealed by a Synthetic Double Mutant Phenotype. Plant Physiol 176, 418-431
4. Tangled localization at the cortical division site of plant cells occurs by several mechanisms. J Cell Sci 124, 270-9
5. The Tangled1 gene is required for spatial control of cytoskeletal arrays associated with cell division during maize leaf development. Plant Cell 10