InterPro domain: IPR044708

This entry represents a nuclear membrane plant protein known as constitutive expression of pathogenesis-related genes 5 (CPR5, also Protein hypersenescence-1), which is part of the nuclear pore complex (NPC) and play a role in gating [ 1 ]. It is involved in plant growth and immunity [ 2 , 2 ]. It plays a role in the control of programmed cell death (PCD), acting as a negative regulator of the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents [ 3 , 4 , 5 , 6 ]. CPR5 also promotes cell division and endoduplication through CPR5-CKI (CYCLIN‐DEPENDENT KINASE INHIBITOR) signalling pathway [ 7 , 7 ].

1. Putative alternative translation start site-encoding nucleotides of CPR5 regulate growth and resistance. BMC Plant Biol 20, 295
2. GeBP/GPL transcription factors regulate a subset of CPR5-dependent processes. Plant Physiol 157, 1232-42
3. Identification of a novel gene HYS1/CPR5 that has a repressive role in the induction of leaf senescence and pathogen-defence responses in Arabidopsis thaliana. Plant J 29, 427-37
4. The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell 9, 1573-84
5. CPR5 is involved in cell proliferation and cell death control and encodes a novel transmembrane protein. Curr Biol 11, 1891-5
6. A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host Microbe 16, 787-94
7. Arabidopsis nucleoporin CPR5 controls trichome cell death through the core cell cycle regulator CKI. Plant Biol (Stuttg) 22, 337-345