InterPro domain: IPR044693

The Shugoshin (SGO) protein family plays a major role in the protection of centromeric cohesion in Drosophila and yeast. This entry represents plant shugoshins, including SGO1 and SGO2 from Arabidopsis [ 1 , 2 ]. SGO1 is required for the maintenance of centromeric cohesion of sister chromatids in meiosis I, but not through the control of AtSYN1/AtREC8 localisation. Together with SGO2, it is required for protection of centromeric cohesion during anaphase I [ 3 ]. However, SGO2 is dispensable for meiosis. In rice, OsSGO1 is also involved in the assembly and maintenance of the synaptonemal complex (SC) during early prophase I [ 4 ]. In maize, ZmSGO1 is required for maintenance of centromeric cohesion before prophase II and correct segregation of chromatids during meiosis II [ 5 ].

1. SGO1 but not SGO2 is required for maintenance of centromere cohesion in Arabidopsis thaliana meiosis. Plant Reprod 26, 197-208
2. SHUGOSHINs and PATRONUS protect meiotic centromere cohesion in Arabidopsis thaliana. Plant J. 77, 782-94
3. Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis. Curr. Biol. 23, 2090-9
4. OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis. Plant J 67, 583-94
5. A REC8-dependent plant Shugoshin is required for maintenance of centromeric cohesion during meiosis and has no mitotic functions. Curr Biol 15, 948-54